Abstract #0575
Nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry
Nadya Pyatigorskaya 1,2 , Michael Sharman 2 , Jean-Christophe Corvol 2,3 , Romain Valabregue 2,3 , Fabrice Poupon 4 , Florence Cornier 2 , Marie Vidailhet 3 , Alexis Brice 2 , and Stephane Lehricy 1,2
1
Centre de NeuroImagerie de Recherche CENIR,
ICM; Service de Neuroradiologie, Groupe Hospitalier
Piti-Salptrire, Paris, France,
2
Institut
du Cerveau et de la Moelle pinire ICM, Paris,
France,
3
CRICM,
INSERM, UPMC Univ Paris 06, CNRS, CRICM, UMR_S975 and
UMR 7225, Paris, France,
4
NeuroSpin,
Commissariat lEnergie Atomique (CEA), Gif-Sur-Yvette,
France
Our goal was investigating iron deposition in the basal
ganglia of patients with Leucine-rich repeat kinase 2
and Parkin-mutation associated Parkinsons disease (PD).
19 affected and presymptomatic mutation-carrying
subjects were compared with 20 idiopathic PD (IPD) and
20 healthy subjects. R2 and R2* values were calculated
in the substantia nigra (SN), the basal ganglia and the
thalamus. R2* values in SN were increased in IPD and
mutation-carrying subjects as compared to controls and
in mutation-carrying as compared to IPD patients. These
results suggest that iron load, analyzed with R2* can be
a biomarker of the nigrostriatal damage in
mutation-carrying subjects.
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