Meeting Banner
Abstract #0576

Association between CVR impairment and cortical thinning in children with sickle cell disease

Junseok Kim 1,2 , Jackie Leung 2 , Jason Lerch 3 , Suzan Williams 4 , and Andrea Kassner 1,2

1 Medical Imaging, University of Toronto, Toronto, Ontario, Canada, 2 Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, 3 MICe, Toronto Center for Phenogenomics, Toronto, Ontario, Canada, 4 Haematology, The Hospital for Sick Children, Toronto, Ontario, Canada

Sickle cell disease (SCD) is a genetic disorder associated with severe cerebrovascular risks and may also disrupt neurological development. Cerebrovascular reactivity (CVR) can assess cerebrovascular health in SCD children. Studies have shown grey matter thinning in SCD children suggesting a connection to neurocogntive decline. We investigated whether CVR is associated with cortical thinning in children with SCD. CVR and grey matter thickness (from T1 anatomical) data were acquired in 42 SCD patients and 15 controls on a 3T MRI. We found a linear relation between the degree of cortical thinning and reduced CVR in multiple regions in the brain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here