Abstract #0592
Serial perfusion imaging using arterial spin labeling in acute ischemic stroke
George William John Harston 1 , Thomas Okell 2 , Fintan Sheerin 3 , Martino Cellerini 3 , Stephen Payne 4 , Peter Jezzard 2 , Michael Chappell 4 , and James Kennedy 1
1
Radcliffe Department of Medicine, University
of Oxford, Oxford, Oxfordshire, United Kingdom,
2
Nuffield
Department of Clinical Neurosciences, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
3
Oxford
University Hospitals NHS Trust, Oxford, Oxfordshire,
United Kingdom,
4
Department
of Engineering Science, University of Oxford, Oxford,
Oxfordshire, United Kingdom
Hypoperfusion underlies the pathophysiology of ischemic
stroke and as such has been used extensively to identify
tissue at risk of infarction. However, presenting
perfusion imaging has not been successfully used to
select patients for treatment. In this observational
cohort study patients with large volume ischemic stroke
were scanned serially with quantitative arterial spin
labeling perfusion imaging to better understand the
natural history of absolute perfusion measurements and
the dynamics of cerebral blood flow over the first hours
and days following a stroke. A marked individual and
temporal heterogeneity of cerebral blood flow was
observed.
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