Abstract #0593
Significant MRI scanner model related differences in hemodynamic imaging: A secondary analysis of 174 dynamic susceptibility contrast MRI studies from the MR RESCUE clinical trial
Jeffry R Alger 1 , David S Liebeskind 1 , Reza Jahan 2 , Jeffrey L Saver 1 , and Chelsea S. Kidwell 3,4
1
Neurology, Geffen School of Medicine, UCLA,
Los Angeles, CA, United States,
2
Radiological
Sciences, Geffen School of Medicine, UCLA, Los Angeles,
CA, United States,
3
Neurology,
University of Arizona, Tuscon, Arizona, United States,
4
Medical
Imaging, University of Arizona, Tuscon, Arizona, United
States
An analysis of scanner model bias in DSC MRI CBF
readings from acute ischemic stroke patients enrolled in
the MR RESCUE clinical trial was performed. The data
were obtained using 16 unique MRI scanner models at 19
imaging centers. Results indicate a statistically
significant scanner model related bias is present in CBF
readings from well perfused tissues as well as
hypoperfused tissues. Future multicenter studies that
use DSC MRI should therefore take scanner model bias
into consideration. Between-patient variability that is
unrelated to scanner model is also present and this
variability is as large as the scanner model-related
variability.
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