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Abstract #0598

HARPERELA Phase Processing for Quantitative Susceptibility Mapping

Wei Li 1,2 , Alexandru V Avram 1,3 , Bing Wu 1,4 , Xue Xiao 1,5 , and Chunlei Liu 1,6

1 Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 3 National Institute of Health, Bethesda, DC, United States, 4 GE Healthcare, Beijing, China, 5 Tsinghua University, Beijing, China, 6 Radiology, Duke University, Durham, NC, United States

3D phase unwrapping and background phase removal are typically two separated preprocessing steps for quantitative susceptibility mapping (QSM). We developed a novel method for integrated phase unwrapping and harmonic background phase removal using Laplacian, named as HARPERELLA. HARPERELLA is fast, robust, easily to implement and yields local tissue phase with similar accuracy to that using the well-known SHARP and PDF methods. To facilitate evaluation and dissemination, we combined HARPERELLA, QSM, susceptibility tensor imaging (STI) algorithms and related graphical user interfaces into a software package, named as STI Suite, which is available online for free academic use.

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