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Abstract #0602

Modulated closed form solution for quantitative susceptibility mapping

Diana Khabipova 1 , Rolf Gruetter 1,2 , and Marques P. Jos 3

1 LIFMET, EPFL, Lausanne, Vaud, Switzerland, 2 Radiology, University of Geneva, Geneva, Geneva, Switzerland, 3 Radiology, University Lausanne, Lausanne, Vaud, Switzerland

Quantitative susceptibility mapping (QSM) has shown the potential delivering iron deposition estimations in deep grey matter structures. Compared to multiple orientation acquisitions, many proposed regularization methods remain time consuming, rely on careful regularization selection and provide inferior results. A recently proposed closed-form solution including an l2-regularization allows fast reconstructions. Our methodology uses additional k-space position dependent modulation, thus avoiding regularizing not ill-posed regions and being effective without showing signs of over-smoothing QSM maps. Optimal modulation enables largely independence from regularization parameters, lower case Greek lambda . Being comparable for lower case Greek lambda values an order of magnitude greater than optimum makes it ideal for unsupervised usage.

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