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Abstract #0605

The best of both worlds: Improved rapid quantitative susceptibility mapping (QSM) by combining closed-form L2 regularization with SDI

Ferdinand Schweser 1 , Andreas Deistung 1 , Xiang Feng 1 , Edsel Daniel Peres Gomez 2 , and Jrgen R Reichenbach 1

1 Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, 2 Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Germany

Quantitative susceptibility mapping (QSM) is a novel post-processing technique for gradient-echo phase data. Schweser et al. have recently presented that inverse filtering with extreme thresholding of the unit dipole response (SDI) yields within seconds susceptibility maps without noise amplification and with a low level of streaking artifacts. Bilgic et al. recently presented a closed-form solution for rapid L2-regularized QSM with a gradient-based penalty (CF-L2) that provides images with even reduced noise level compared to SDI . In this contribution, we show that combining CF-L2 with SDI can considerably reduce reconstruction artifacts.

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