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Abstract #0606

A joint background field removal and dipole deconvolution approach for quantitative susceptibility mapping in the liver

Samir D. Sharma 1 , Diego Hernando 1 , Debra E. Horng 1 , and Scott B. Reeder 1,2

1 Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2 Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, United States

Noninvasive quantification of liver iron concentration is important for the detection and staging of iron overload as well as for effective longitudinal monitoring during treatment. Magnetic susceptibility is a fundamental property of tissue that has a well-defined relationship to iron concentration. Quantitative susceptibility mapping (QSM) methods have been developed in the brain to quantify the concentrations of localized iron deposits. The purpose of this work was to develop a QSM technique for the liver and to demonstrate its feasibility for measuring susceptibility in the liver, which may serve as an imaging biomarker of liver iron overload.

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