Abstract #0607
On The Role of Physiological Fluctuations in Quantitative Gradient Echo MRI
Jie Wen 1 , Anne H. Cross 2 , and Dmitriy A. Yablonskiy 1
1
Mallinckrodt Institute of Radiology,
Washington University in St. Louis, St. Louis, MO,
United States,
2
Neurology,
Washington University in St. Louis, St. Louis, MO,
United States
Physiological fluctuations in biological tissues
adversely affect MR images. In this abstract, a
navigator- and a keyhole-based methods are used to
reduce physiologically-induced artifacts. We study
brains in normal subjects and subjects with multiple
sclerosis and demonstrate that employed strategies
substantially reduce the width of the R2*=1/T2*
distribution within a human brain and provide
significant improvement in quantifying tissue damage in
multiple sclerosis. We also show improvement in the
quality of GEPCI, SWI and QSM images. These correcting
strategies greatly improve the reliability of
quantitative gradient echo MRI techniques.
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