Abstract #0612
Limits of liver fat quantification in the presence of severe iron overload
Diego Hernando 1 , Samir D. Sharma 1 , and Scott B. Reeder 1,2
1
Radiology, University of Wisconsin-Madison,
Madison, WI, United States,
2
Medicine,
University of Wisconsin-Madison, Madison, WI, United
States
Chemical shift-encoded fat quantification requires the
acquisition of images at multiple echo times to enable
fat-water separation and R2* estimation. Excessive
tissue iron deposition can severely increase R2*,
complicating fat quantification. In this work, we assess
the feasibility of chemical shift encoded liver fat
quantification in the presence of liver iron using
theoretical analysis and in vivo patient data. Our
results demonstrate that fat quantification fails at
high iron levels when using standard protocols. The use
of shorter initial echo time and echo spacing
significantly extends the range of iron levels over
which accurate fat quantification is possible.
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