Quantification of the Cerebral Microvasculature using High-Resolution BOLD-Based Vessel Size Imaging at 3 Tesla

We present a non-invasive approach for characterizing the vasculature in the capillary regime with an effective in-plane resolution of 2mm at 3 Tesla by employing gradient echo sampling of FID and spin echo (GESFIDE) with periodically rotated overlapping parallel lines with enhanced reconstruction echo planar imaging (PROPELLER-EPI). The analysis of the blood oxygenation level dependency related signal changes provoked by inhaling different gas mixtures (air, carbogen) resulted in quantitative maps of vessel radius, deoxygenated blood volume, and venous vessel density that enable discrimination of anatomic structures. Furthermore, average values across 23 equally-aged subjects are presented for different tissue types.

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