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Abstract #0635

Contributions to Susceptibility From Iron and Demyelination in Multiple Sclerosis Lesions

Cynthia Wisnieff 1,2 , Sriram Ramanan 3 , David Pitt 3 , John Olesik 4 , and Yi Wang 1,2

1 Biomedical Engineering, Cornell University, Ithaca, New York, United States, 2 Radiology, Weill Cornell Medical College, New York, New York, United States, 3 Neurology, Yale University, New Haven, Connecticut, United States, 4 Ohio State University, Ohio, United States

We assess the contributions of iron deposition and demyelination to the measured susceptibility of multiple sclerosis (MS) lesions in MRI. In this work we examine histological findings of the quantitative distribution of iron from laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), the distribution of demyelination from myelin basic protein (MBP) labeling, and susceptibility distribution from QSM. This preliminary study shows that the contribution to the total observed susceptibility change in MS lesion is from both the measured iron distribution in the lesion and demyelination in the center of the lesion.

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