Abstract #0635
Contributions to Susceptibility From Iron and Demyelination in Multiple Sclerosis Lesions
Cynthia Wisnieff 1,2 , Sriram Ramanan 3 , David Pitt 3 , John Olesik 4 , and Yi Wang 1,2
1
Biomedical Engineering, Cornell University,
Ithaca, New York, United States,
2
Radiology,
Weill Cornell Medical College, New York, New York,
United States,
3
Neurology,
Yale University, New Haven, Connecticut, United States,
4
Ohio
State University, Ohio, United States
We assess the contributions of iron deposition and
demyelination to the measured susceptibility of multiple
sclerosis (MS) lesions in MRI. In this work we examine
histological findings of the quantitative distribution
of iron from laser ablation inductively coupled plasma
mass spectrometry (LA-ICP-MS), the distribution of
demyelination from myelin basic protein (MBP) labeling,
and susceptibility distribution from QSM. This
preliminary study shows that the contribution to the
total observed susceptibility change in MS lesion is
from both the measured iron distribution in the lesion
and demyelination in the center of the lesion.
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