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Abstract #0682

GluCEST imaging of Tumor Protease Activity

Mohammad Haris 1,2 , Anup Singh 1 , Imran Mohammed 3 , Ranjit Ittyerah 4 , Kavindra Nath 4 , Ravi Prakash R Nanga 1 , Catherine Debrosse 1 , Feliks Kogan 1 , Kejia Cai 1,5 , Harish Poptani 4 , Damodar Reddy 1 , Hari Hariharan 1 , and Ravinder Reddy 1

1 CMROI, Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2 Research Branch, Sidra Medical and Research Center, Doha, Qatar, 3 Department of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 4 Molecular Imaging, Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 5 CMRR 3T Research Program, University of Illinois at Chicago, Chicago, IL, United States

We propose a noninvasive MRI method that is capable of measuring expression of cathepsin proteases in tumors in vivo. Degradation of L-poly glutamate by cathepsins in to glutamate or smaller peptide fragments exposes amine protons, which can be monitored through chemical exchange saturation transfer (CEST) imaging. In the current study, we have shown the feasibility of mapping cathepsins in tumor cells line and rat model of brain tumor using CEST imaging technique.

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