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Abstract #0686

Hot-spot 19F imaging of stem cell transplantation into the intrathecal space in a large animal model

Miroslaw Janowski 1,2 , Guan Wang 1 , Jiadi Xu 3 , Monica Pearl 1 , Gokhuldass Mohandas 1 , Amnon Bar-Shir 1 , Monika Barczewska 4 , Joanna Wojtkiewicz 4 , Aleksandra Habich 4 , Wojciech Maksymowicz 4 , Jeff W.M. Bulte 1 , Dara Kraitchman 1 , and Piotr Walczak 1,5

1 The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States, 2 NeuroRepair Department, Mossakowski Medical Research Centre PAS, Warsaw, Mazovia, Poland, 3 F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, Maryland, United States, 4 Department of Neurology and Neurosurgery, University of Warmia and Mazury, Olsztyn, Varmia and Masuria, Poland, 5 Department of Radiology, University of Warmia and Mazury, Varmia and Masuria, Poland

An intrathecal route was found to be a minimally invasive and potentially efficient method of stem cell delivery to the spinal cord. However, that approach is highly challenging due to uncertain cell distribution. Cell tracking with proton imaging proved difficult due to omnipresent magnetic field inhomogeneity. We have shown that suspending stem cells in a hydrogel improves the targeted injection. Labeling of the hydrogel with fluorine nanoparticles enables detailed and quantitative depiction of stem cell distribution. The use of fluorine image-guidance enables a very precise deployment of stem cells within the intrathecal space.

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