Abstract #0685
MRI guidance of Doxorubicin release from liposomes stimulated by pulsed low intensity non-focused Ultrasound in an experimental tumor model
Silvia Rizzitelli 1 , Pierangela Giustetto 1,2 , Juan Carlos Cutrin 1,3 , Marta Ruzza 1 , Cinzia Boffa 1 , Daniela Delli Castelli 1 , Valeria Menchise 4 , Filippo Molinari 5 , Silvio Aime 1,2 , and Enzo Terreno 1,2
1
Department of Molecular Biotechnology and
Health Sciences, Molecular Imaging Center, University of
Torino, Torino, Italy,
2
Center
for Preclinical Imaging, University of Torino,
Colleretto Giacosa, Torino, Italy,
3
(UBA-CONICET),
ININCA, Buenos Aires, Argentina,
4
Institute
for Biostructures and Bioimages (CNR) c/o Molecular
Biotechnology Center, University of Torino, Torino,
Italy,
5
Biolab,
Department of Electronics and Telecommunications,
Politecnico di Torino, Torino, Italy
Doxorubicin is one of the most effective antitumoral
drugs, which is clinically administered in liposomal
form to improve the therapeutic index and reduce side
effects. Since liposomes are not able to deeply diffuse
in the tumor, several methods to promote the release of
the drug at the target site have been proposed. In this
contribution, we used pulsed low-intensity non-focused
US (pLINFU) as physical trigger to stimulate a mechanic
release of the drug from stealth liposomes. The
co-encapsulation of the MRI agent Gadoteridol provided a
non invasive and efficient MRI guidance to monitor the
drug release.
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