Abstract #0684
pH-nanosensors for monitoring the cell fate after transplantation into diabetic mice using CEST MRI
Dian R. Arifin 1,2 , Kannie W.Y. Chan 1,2 , Peter C.M. van Zijl 1,3 , Daniel S. Warren 4 , Zhaoli Sun 4 , Jeff W.M. Bulte 1,2 , and Michael T. McMahon 1,3
1
Russell H. Morgan Radiology and Radiological
Science, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
2
Institute
for Cell Engineering, The Johns Hopkins University
School of Medicine, Baltimore, MD, United States,
3
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States,
4
Department
of Surgery, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States
Imaging the functionality of transplanted islet cells in
diabetes is important for proper post-treatment
follow-up. Insulin secretion is accompanied by a
decrease in pH, and the ability to image pH changes
could be used to monitor release of insulin. We
investigated the potential of pH-nanosensors
incorporated in alginate microcapsules to sense insulin
release in diabetic mice using CEST MRI, which detects
protons exchanging with water at a rate sensitive to pH.
We show that a decrease in CEST contrast of the
microcapsules may correspond to an increase in insulin
secretion, indicating potential for application to
monitoring cell function in diabetes.
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