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Abstract #0690

Modulating Activity in the Olfactory Bulb Leads to Reversible Changes in Size and Alter Migration of New Neurons

Nikorn Pothayee 1 , Diana Cummings 2 , Leonardo Belluscio 2 , and Alan Koretsky 1

1 Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States, 2 Developmental Neural Plasticity Section, NINDS, NIH, Bethesda, MD, United States

In mammalian, the migrating new neuron precursors play an important role in maintaining neuronal homeostasis in olfactory bulbs (OB). Various techniques based on optical and electron microscopy have been used to study cell migration and neuronal turnover in OB. However, none of these techniques enable longitudinal study of the whole brain within the living subject. We utilized in situ MRI labeling in combination with MRI volumetry to address the question of whether change in olfactory sensory level alter migrating speed and pattern of NPC integration in OB as well as changes in OB sizes in response to alteration of activity deprivation and recovery.

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