Meeting Banner
Abstract #0691

Reduced intracellular mobility underlies manganese relaxivity in mouse brain in vivo : MRI at 2.35 and 9.4 T

Takashi Watanabe 1 , Jens Frahm 1 , and Thomas Michaelis 1

1 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut fr biophysikalische Chemie, Gttingen, Germany

One day after systemic administration of manganese, increases of the longitudinal relaxation rate ∆R 1 in several brain regions are significantly higher at 2.35 T than at 9.4 T. In contrast, ∆R 1 after intraventricular Gd-DTPA administration are not significantly different. The pronounced field dependence of manganese relaxivities indicates a reduced mobility of manganese in vivo by confinement to a viscous fluid compartment and/or due to macromolecular binding. This is further supported by a slow release of manganese from nerve cells post mortem , which occurs despite a high permeability of damaged cellular membranes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here