Reduced intracellular mobility underlies manganese relaxivity in mouse brain in vivo : MRI at 2.35 and 9.4 T

One day after systemic administration of manganese, increases of the longitudinal relaxation rate ∆R ₁ in several brain regions are significantly higher at 2.35 T than at 9.4 T. In contrast, ∆R ₁ after intraventricular Gd-DTPA administration are not significantly different. The pronounced field dependence of manganese relaxivities indicates a reduced mobility of manganese in vivo by confinement to a viscous fluid compartment and/or due to macromolecular binding. This is further supported by a slow release of manganese from nerve cells post mortem , which occurs despite a high permeability of damaged cellular membranes.

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