Abstract #0692
Longitudinal monitoring of metabolic alterations in cuprizone mouse model of Multiple Sclerosis using 1 H magnetic resonance spectroscopy
Jasmien Orije 1 , Firat Kara 1 , Caroline Guglielmetti 1 , Jelle Praet 1 , Marleen Verhoye 1 , Peter Ponsaerts 2 , and Annemie Van der Linden 1
1
Bio-Imaging Lab, University of Antwerp,
Wilrijk, Antwerp, Belgium,
2
Laboratory
of Experimental Hematology, University of Antwerp,
Wilrijk, Antwerp, Belgium
In this study, we employed quantitative in vivo 1H MRS
to longitudinally monitor metabolic changes in the
corpus callosum of C57BL/6 mice receiving a 0.2%
cuprizone supplemented diet. Significant alterations in
N-acetylaspartate, glycerophosphorylcholine, taurine and
macromolecules and lipids were observed in the early
demyelination phase (week 4 and 6) in the cuprizone fed
mice compared to control mice, fed with standard rodent
chow. Six week after the cuprizone withdrawal, these
metabolic changes were no longer present suggesting that
metabolic changes observed with
1
H
MRS reflect key pathological features, such as
demyelination, inflammation and axonal injury, caused by
the cuprizone treatment.
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