Abstract #0693
Correlations between BOLD and neurochemical responses measured in the human visual cortex at 7T
Petr Bednarik 1,2 , Ivan Tkac 1 , Federico Giove 3,4 , Dinesh K Deelchand 1 , and Silvia Mangia 1
1
CMRR - Dept. of Radiology, University of
Minnesota, Minneapolis, MN, United States,
2
CEITEC
- Central European Institute of Technology, Masaryk
University, Brno, Czech Republic,
3
Magnetic
Resonance for Brain Investigation Lab, Enrico Fermi
Center, Roma, Italy,
4
Dipartimento
di Fisica, Sapienza Universit di Roma, Roma, Italy
Functional magnetic resonance spectroscopy (fMRS) is
able to measure very small changes of metabolite
concentrations during visual stimulation. These changes
are ascribed to increased energetic neuronal oxidative
metabolism. The aim of the current study was to
correlate the neurochemical responses measured by fMRS
with the metabolic/hemodynamic responses measured by the
BOLD effect. Significant correlation between BOLD-fMRI
signals and glutamate concentration changes during
visual stimulation was found. Additionally, higher
baseline GABA concentration measured at baseline
predicted lower BOLD responses.
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