Abstract #0695
An Investigation of Microstructural Tissue Damage in Systemic Lupus Erythematosus (SLE) with Neurological and Psychiatric Symptoms using Diffusion Weighted Spectroscopy (DWS) at 7T
Ece Ercan 1 , Emily T. Wood 2,3 , Mark van Buchem 4 , Andrew G. Webb 1 , and Itamar Ronen 1
1
C.J. Gorter Center for High Field MRI,
Department of Radiology, Leiden University Medical
Center, Leiden, Netherlands,
2
NINDS,
National Institutes of Health, Bethesda, Maryland,
United States,
3
Dept
of Neuroscience, Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
4
Department
of Radiology, Leiden University Medical Center, Leiden,
Netherlands
Conventional MRI from SLE patients with neurological and
psychiatric symptoms (SLEwNP) frequently appear normal
and fail to explain the clinical symptoms, making the
diagnostic procedure rather difficult and restricted to
per exclusionem. Here we utilize DWS of brain
metabolites in normal appearing white matter in the CC
to investigate the tissue microstructural correlate of
SLEwNP for the first time. The results suggest a
disruption of astrocytic structure or physiology, which
is in line with the inflammatory nature of the disease
and show that ADC(tCho) may potentially become a
biomarker for SLEwNP.
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