Age Dependence of the Metabolite Diffusion Tensor in Human Brain using Proton-Echo-Planar-Spectroscopic-Imaging
Alec Landow 1 , Elena Ackley 2 , Stephen R. Dager 3 , Dennis Shaw 3,4 , Mindy Dixon 4 , and Stefan Posse 1,2
Department of Physics and Astronomy,
University of New Mexico, Albuquerque, NM, United
of Neurology, University of New Mexico, Albuquerque, NM,
of Radiology, University of Washington, Seattle, WA,
Children's Hospital, Seattle, WA, United States
Diffusion tensor spectroscopic imaging (DTSI) in human
brain provides intracellular markers for studying axonal
development. DTSI was implemented at 3 Tesla using
cardiac gated proton-echo-planar-spectroscopic-imaging
(PEPSI). Movement-related phase and amplitude errors
were corrected using spatially localized navigators.
Data were acquired in 6 healthy volunteers (age range: 3
months 58 years) using 1-4.5 cc voxel size, bmax =
1734 s/mm2, and 6 gradient directions. The apparent
diffusion coefficients of Cho, Cr and NAA in a 3-month
old subject were significantly higher and the fractional
anisotropy values were lower than those in the adults,
consistent with studies of water diffusion.
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