Abstract #0696
Age Dependence of the Metabolite Diffusion Tensor in Human Brain using Proton-Echo-Planar-Spectroscopic-Imaging
Alec Landow 1 , Elena Ackley 2 , Stephen R. Dager 3 , Dennis Shaw 3,4 , Mindy Dixon 4 , and Stefan Posse 1,2
1
Department of Physics and Astronomy,
University of New Mexico, Albuquerque, NM, United
States,
2
Department
of Neurology, University of New Mexico, Albuquerque, NM,
United States,
3
Department
of Radiology, University of Washington, Seattle, WA,
United States,
4
Seattle
Children's Hospital, Seattle, WA, United States
Diffusion tensor spectroscopic imaging (DTSI) in human
brain provides intracellular markers for studying axonal
development. DTSI was implemented at 3 Tesla using
cardiac gated proton-echo-planar-spectroscopic-imaging
(PEPSI). Movement-related phase and amplitude errors
were corrected using spatially localized navigators.
Data were acquired in 6 healthy volunteers (age range: 3
months 58 years) using 1-4.5 cc voxel size, bmax =
1734 s/mm2, and 6 gradient directions. The apparent
diffusion coefficients of Cho, Cr and NAA in a 3-month
old subject were significantly higher and the fractional
anisotropy values were lower than those in the adults,
consistent with studies of water diffusion.
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