Lower glutathione (GSH) concentration in the posterior cingulate cortex of healthy human elders measured at 7 T

Oxidative stress occurs at an early stage of age related cognitive decline. Ascorbate (Asc, vitamin C) and glutathione (GSH) are key contributors to the antioxidant network. Although lower ¹ H MRS GSH signal has been measured in the occipital cortex (OCC) of an elder cohort, that finding could have been confounded by differing transverse relaxation ( T ₂ ). The purpose of this work was to utilize short echo time ¹ H MRS to overcome confounding by age associated difference in T ₂ to quantify GSH concentration in the aging brain in OCC and posterior cingulate cortex (PCC, pertinent to the pathology of Alzheimers disease).

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