Meeting Banner
Abstract #0697

Lower glutathione (GSH) concentration in the posterior cingulate cortex of healthy human elders measured at 7 T

Malgorzata Marjanska 1 and Melissa Terpstra 1

1 Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Oxidative stress occurs at an early stage of age related cognitive decline. Ascorbate (Asc, vitamin C) and glutathione (GSH) are key contributors to the antioxidant network. Although lower 1 H MRS GSH signal has been measured in the occipital cortex (OCC) of an elder cohort, that finding could have been confounded by differing transverse relaxation ( T 2 ). The purpose of this work was to utilize short echo time 1 H MRS to overcome confounding by age associated difference in T 2 to quantify GSH concentration in the aging brain in OCC and posterior cingulate cortex (PCC, pertinent to the pathology of Alzheimers disease).

This abstract and the presentation materials are available to members only; a login is required.

Join Here