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Abstract #0706

High resolution MRI and high sensitive 31P MRS of axillary lymph nodes at 7T

Debra S Rivera 1 , Jannie P Wijnen 2 , Wybe J. M. van der Kemp 2 , Alexander J Raaijmakers 2 , Peter R Luijten 2 , and Dennis WJ Klomp 2

1 Neurophysics, Max Planck Institute, Leipzig, Germany, 2 Univercity Medical Center Utrecht, Netherlands

Lymph node treatment response predicts 5-year survival. Insufficient monitoring methods slow drug development and breakthroughs in individualized treatment. Phospholipid metabolism indicates malignant transformation, thus preclinical drug development uses spectroscopy. Combining specialized RF hardware with 7T, we shrink voxels to clinically relevant volumes in vivo (1.2 cm isotropic). The setup is safe and compatible with existing breast coils. We present images of <1 cm nodes, and the first 31P spectra from an axilla lymph node in vivo. With signal visible just above the noise floor in a healthy volunteer, the hardware holds potential for monitoring treatment response in malignant lymph nodes.

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