High resolution MRI and high sensitive 31P MRS of axillary lymph nodes at 7T
Debra S Rivera 1 , Jannie P Wijnen 2 , Wybe J. M. van der Kemp 2 , Alexander J Raaijmakers 2 , Peter R Luijten 2 , and Dennis WJ Klomp 2
Neurophysics, Max Planck Institute, Leipzig,
Medical Center Utrecht, Netherlands
Lymph node treatment response predicts 5-year survival.
Insufficient monitoring methods slow drug development
and breakthroughs in individualized treatment.
Phospholipid metabolism indicates malignant
transformation, thus preclinical drug development uses
spectroscopy. Combining specialized RF hardware with 7T,
we shrink voxels to clinically relevant volumes in vivo
(1.2 cm isotropic). The setup is safe and compatible
with existing breast coils. We present images of <1 cm
nodes, and the first 31P spectra from an axilla lymph
node in vivo. With signal visible just above the noise
floor in a healthy volunteer, the hardware holds
potential for monitoring treatment response in malignant
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