Abstract #0722
Simultaneous measurement of microvascular and macrovascular blood flow and oxygenation in the leg
Erin K Englund 1 , Zachary B Rodgers 2 , Michael C Langham 3 , Emile R Mohler III 4 , Thomas F Floyd 5 , and Felix W Wehrli 3
1
University of Pennsylvania, Philadelphia,
PA, United States,
2
Department
of Bioengineering, University of Pennsylvania,
Philadelphia, PA, United States,
3
Department
of Radiology, University of Pennsylvania, Philadelphia,
PA, United States,
4
Department
of Medicine, University of Pennsylvania, Philadelphia,
PA, United States,
5
Department
of Anesthesiology, Stony Brook University, Stony Brook,
NY, United States
A method to simultaneously measure perfusion, arterial
velocity, venous oxygen saturation, and skeletal muscle
T
2
* using an interleaved pulsed arterial spin
labeling and velocity-encoded multi-echo GRE sequence is
presented. The method, termed velocity-encoded
Perfusion, Intravascular Venous Oxygen saturation and T
2
*
(velocity-encoded PIVOT) was assessed in healthy
subjects during a series of ischemia reperfusion
paradigms. Results demonstrate that the method is
capable of faithfully measuring all four parameters at
3-second temporal resolution. Dynamic measurement of
these parameters was also completed during isometric
plantar flexion contractions. Results suggest that this
technique may be useful in developing biophysical models
of muscle metabolism.
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