Abstract #0723
Brain tumor oxygen saturation mapping with magnetic resonance imaging corrected by a local hematocrit mapping assessed by nuclear imaging
Benjamin Lemasson 1,2 , Alexis Broisat 3,4 , Pauline Busieau 1,2 , Rgine Farion 1,2 , Mitra Ahmadi 3,4 , Sandrine Bacot 3,4 , Catherine Ghezzi 3,4 , Chantal Rmy 1,2 , and Emmanuel Barbier 1,2
1
U836, Inserm, GRENOBLE, France,
2
Grenoble
Institut des Neurosciences, Universit Joseph Fourier,
GRENOBLE, France,
3
U1039,
Inserm, GRENOBLE, France,
4
Radiopharmaceutiques
Biocliniques, Universit Joseph Fourier, GRENOBLE,
France
We evaluated the impact of the local hematocrit (Hct)
when mapping the brain tumor oxygen saturation (StO
2
).
A multimodal experiment (MRI and autoradiography of 2
different isotopes) was performed on 8 rats bearing a
brain tumor. The tumor Hct level, assessed by
autoradiography, was significantly reduced as compared
to healthy striatum. Using, for each animal, the Hct to
compute the StO
2
voxel-wise
led to a significant reduction in tumor oxygenation in
comparison to that of the healthy striatum. Our results
indicate that change in Hct should not be overlooked
when assessing oxygenation in brain tumors or in other
brain diseases.
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