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Abstract #0724

Pseudo Extravasation Rate Constant of Dynamic Susceptibility Enhanced Magnetic Resonance Imaging Determined From Pharmacokinetic First Principles

Xin Li 1 , Csanad Varallyay 2 , Seymur Gahramonov 2 , William D Rooney 1 , and Edward A Neuwelt 2

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, 2 Department of Neurology, Oregon Health & Science University, Portland, Oregon, United States

Though widely adopted for brain perfusion measurement, Dynamic Susceptibility Contrast (DSC) Magnetic Resonance Imaging (MRI) with low molecular weight Gadolinium (Gd) contrast reagent (CR) is often confounded by CRs leakage into intersitium space. Based on pharmacokinetic first principles, we demonstrate a fast leakage correction method similar to that of the Patlak plot. This linearization approach uniquely identifies the leakage rate constant and significantly simplifies relative cerebral blood volume (rCBV) quantification.

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