Simutaneous measurement of pharmacokinetic model parameters and T 1 /B 1 using Active Contrast Encoding MRI

In DCE-MRI studies, accurate estimation of pharmacokinetic model parameters requires B ₁ -corrected T ₁ values. However, it is not trivial to measure B ₁ and T ₁ accurately in addition to the long scan time. In this study, we proposed a novel approach, namely active contrast encoding (ACE) MRI, to measure both B ₁ and T ₁ values along with kinetic parameters from a single DCE-MRI data. A proof-of-concept study was conducted to demonstrate the proposed method using numerical simulations and an in vivo mouse study, and to show that ACE-MRI can eliminate the need to have separate B ₁ and T ₁ mapping procedures.

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