Prospects for rapid CMRO 2 quantification with interleaved TRUST, susceptometry-based oximetry, and phase-contrast MRI

Susceptometry-based oximetry (SBO) and T ₂ -Relaxation-Under-Spin-Tagging (TRUST) are two promising methods for global CMRO ₂ quantification. However, while SBO offers high temporal resolution, it is sensitive to vessel geometry and requires robust background field removal. TRUST does not have such limitations, but suffers from inherently low temporal resolution and must quantify flow from a separate PC-MRI measurement. By inserting a flow-encoded, SBO pulse sequence within the T ₁ recovery period of TRUST and using fewer effective echo times for T ₂ fitting, we demonstrate that it is possible to achieve T ₂ -based CMRO ₂ quantification in only seconds, while directly comparing SBO- and T ₂ -derived Y _v .

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