Abstract #0751
Prospects for rapid CMRO 2 quantification with interleaved TRUST, susceptometry-based oximetry, and phase-contrast MRI
Zachary B Rodgers 1 , Erin K Englund 1 , Michael C Langham 1 , and Felix W Wehrli 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States
Susceptometry-based oximetry (SBO) and T
2
-Relaxation-Under-Spin-Tagging
(TRUST) are two promising methods for global CMRO
2
quantification.
However, while SBO offers high temporal resolution, it
is sensitive to vessel geometry and requires robust
background field removal. TRUST does not have such
limitations, but suffers from inherently low temporal
resolution and must quantify flow from a separate PC-MRI
measurement. By inserting a flow-encoded, SBO pulse
sequence within the T
1
recovery
period of TRUST and using fewer effective echo times for
T
2
fitting,
we demonstrate that it is possible to achieve T
2
-based
CMRO
2
quantification
in only seconds, while directly comparing SBO- and T
2
-derived
Y
v
.
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