Abstract #0752
Regional quantification of cerebral venous oxygenation from MRI susceptibility mapping during hypercapnia
Audrey P Fan 1,2 , Karleyton C Evans 1,3 , Jeffrey N Stout 2,4 , Bruce R Rosen 2,4 , and Elfar Adalsteinsson 1,4
1
Electrical Engineering and Computer Science,
Massachusetts Institute of Technology, Cambridge, MA,
United States,
2
Radiology,
Athinoula A. Martinos Center for Biomedical Imaging,
Charlestown, MA, United States,
3
Psychiatry,
Massachusetts General Hospital, Boston, MA, United
States,
4
Health
Sciences and Technology, Harvard-MIT, Cambridge, MA,
United States
The purpose of the study was to validate regional
measurements of oxygen extraction fraction (OEF) in
individual cerebral veins derived from quantitative
susceptibility mapping. Flow-compensated gradient echo
images and arterial spin labeling perfusion images were
acquired during eucapnia and moderate hypercapnia in
eight healthy volunteers. Regional changes in perfusion
were used to predict local oxygenation changes and
compared with quantitative susceptibility mapping (QSM)-based
OEF estimates in veins draining the cingulate,
occipital, parietal, and frontal cortices. Measured OEF
changes during hypercapnia from MR susceptibility show
good agreement with predictions based on regional flow
observations and no change in the cerebral metabolic
rate of oxygen CMRO
2
, and suggests that
regional estimates of OEF in vessels from QSM maps are
reliable.
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