Normalizing cerebrovascular reactivity map via concomitant CO2 and O2 challenge

Cerebrovascular reactivity (CVR), measured by combining BOLD MRI and hypercapnia, is an important marker of cerebrovascular function. An undesirable feature of current CVR mapping results is that the image shows very strong contrast in large drains due to large blood volume in these voxels, which reduces the conspicuity of true CVR abnormalities. The present work demonstrates that normalizing CO2-CVR by O2-reactivity can effectively reduce the influence of cerebral blood volume on the results. Furthermore, a novel breathing paradigm with concomitant CO2/O2 challenge is developed to obtain CO2 and O2 reactivity maps in a single scan without increasing the study duration.

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