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Abstract #0760

Imaging astrocyte reactivity using gluCEST

Julien Flament 1 , Maria-Angeles Carrillo-de Sauvage 2,3 , Julien Valette 2,3 , and Carole Escartin 2,3

1 U986 Inserm, MIRCen - CEA/Inserm, Fontenay-aux-Roses, France, 2 CEA-MIRCen, Fontenay-aux-Roses, France, 3 CNRS URA 2210, Fontenay-aux-Roses, France

This study describes the possibility to image spatial extension of astrocyte reactivity using gluCEST. A model of selective astrocyte activation was used by overexpression of the cytokine ciliary neurotrophic factor (CNTF) in rat striatum. The model was first characterized by NMR spectroscopy, showing a decrease of glutamate (18%, n=9). GluCEST images were acquired on 5 rats and showed decrease of MTRasym reflecting glutamate variation. Interestingly, the area of lower gluCEST contrast matched well with the area containing activated astrocytes (vimentin positive area in postmortem studies). These results suggest that glutamate decrease could be a surrogate marker of astrocyte reactivity.

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