Abstract #0760
Imaging astrocyte reactivity using gluCEST
Julien Flament 1 , Maria-Angeles Carrillo-de Sauvage 2,3 , Julien Valette 2,3 , and Carole Escartin 2,3
1
U986 Inserm, MIRCen - CEA/Inserm, Fontenay-aux-Roses,
France,
2
CEA-MIRCen,
Fontenay-aux-Roses, France,
3
CNRS
URA 2210, Fontenay-aux-Roses, France
This study describes the possibility to image spatial
extension of astrocyte reactivity using gluCEST. A model
of selective astrocyte activation was used by
overexpression of the cytokine ciliary neurotrophic
factor (CNTF) in rat striatum. The model was first
characterized by NMR spectroscopy, showing a decrease of
glutamate (18%, n=9). GluCEST images were acquired on 5
rats and showed decrease of MTRasym reflecting glutamate
variation. Interestingly, the area of lower gluCEST
contrast matched well with the area containing activated
astrocytes (vimentin positive area in postmortem
studies). These results suggest that glutamate decrease
could be a surrogate marker of astrocyte reactivity.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
