Abstract #0765
MTC free APT and rNOE-CEST Images of Human Brain at 7T
Xiang Xu 1,2 , Nirbhay N. Yadav 1,2 , Craig K. Jones 1,2 , Haifeng Zeng 1,2 , Jinyuan Zhou 1,2 , Peter C. M. van Zijl 1,2 , and Jiadi Xu 1,2
1
Radiology Department, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States,
2
F.
M. Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Research Institute, Baltimore, MD,
United States
The Variable Delay Multi-Pulse (VDMP) CEST method can
image slow exchange processes such as Amide Proton
Transfer (APT) and exchange relayed Nuclear Overhauser
Enhancement (rNOE) without the need for a full
Z-spectrum by subtracting signals acquired at two pulse
delays. Here we examine the use of the VDMP-CEST
sequence to the human brain, where the inter-pulse delay
is optimized to remove conventional magnetization
transfer contrast (MTC), allowing MTC free APT and rNOE
images to be obtained. The results show similar rNOE
effects in gray and white matter, while APT effects are
higher in gray matter than in white matter.
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