Inverse Z-spectrum analysis for clean NOE and amide CEST-MRI application to human glioma
Moritz Zaiss 1 , Johannes Windschuh 1 , Jan-Eric Meissner 1 , Daniel Paech 2,3 , Alexander Radbruch 2,3 , and Peter Bachert 1
Dept. Medical Physics in Radiology, German
Cancer Research Center (DKFZ), Heidelberg, Germany,
of Neuroradiology, University of Heidelberg, Heidelberg,
Neurooncologic Imaging, German Cancer Research Center (DKFZ),
We present NOE and APT-CEST imaging data of glioma
patients measured at 7 T. Clean CEST evaluation was
achieved by multi-Lorentzian fitting in combination with
the recently proposed AREX evaluation, based on the
inverse metric of Z-spectra. The spillover, MT and T1
corrected AREX-maps of isolated APT and NOE show very
different contrast compared to uncorrected CEST data of
three glioblastoma patients.
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