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Abstract #0766

Inverse Z-spectrum analysis for clean NOE and amide CEST-MRI application to human glioma

Moritz Zaiss 1 , Johannes Windschuh 1 , Jan-Eric Meissner 1 , Daniel Paech 2,3 , Alexander Radbruch 2,3 , and Peter Bachert 1

1 Dept. Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2 Dept. of Neuroradiology, University of Heidelberg, Heidelberg, Germany, 3 Section Neurooncologic Imaging, German Cancer Research Center (DKFZ), Heidelberg, Germany

We present NOE and APT-CEST imaging data of glioma patients measured at 7 T. Clean CEST evaluation was achieved by multi-Lorentzian fitting in combination with the recently proposed AREX evaluation, based on the inverse metric of Z-spectra. The spillover, MT and T1 corrected AREX-maps of isolated APT and NOE show very different contrast compared to uncorrected CEST data of three glioblastoma patients.

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