Abstract #0767
Nuclear Overhauser Enhancement (NOE) Mediated Chemical Exchange Saturation Transfer (CEST) Imaging At 7 Tesla In Glioblastoma Patients
Daniel Paech 1,2 , Jan Eric Meissner 3 , Johannes Windschuh 3 , Benedikt Wiestler 4 , Jan Oliver Neumann 5 , Heinz Peter Schlemmer 6 , Wolfgang Wick 4 , Armin Nagel 3 , Marc Ladd 3 , Martin Bendszus 1 , Peter Bachert 3 , Moritz Zaiss 3 , and Alexander Radbruch 1,2
1
Department of Neuroradiology, University of
Heidelberg Medical Center, Heidelberg, BW, Germany,
2
Neurooncologic
Imaging, Department of Radiology, German Cancer Research
Center (Deutsches Krebsforschungszentrum, DKFZ),
Heidelberg, BW, Germany,
3
Department
of Medical Physics in Radiology, German Cancer Research
Center (Deutsches Krebsforschungszentrum, DKFZ),
Heidelberg, BW, Germany,
4
Department
of Neurooncology, University of Heidelberg Medical
Center, Heidelberg, BW, Germany,
5
Department
of Neurosurgery, University of Heidelberg Medical
Center, Heidelberg, BW, Germany,
6
Department
of Radiology, German Cancer Research Center (Deutsches
Krebsforschungszentrum, DKFZ), Heidelberg, BW, Germany
Chemical Exchange Saturation Transfer (CEST) offers a
contrast sensitive to endogenous mobile proteins and
changes in pH. In our clinical prospective study we
investigated Nuclear Overhauser Enhancement (NOE)
mediated CEST on a 7T whole body MRI scanner in 11 newly
diagnosed and histologically proven glioblastoma
patients. Three-dimensional CEST data was co-registrated
and compared with contrast enhanced T1-weighted (ce-T1)
and T2-weighted sequences. CEST enabled imaging of hot
spots within the tumor that were not visible on ce-T1 or
T2-weighted images and displayed a surrounding tumor
edema significantly smaller than on T2-weighted images.
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