Abstract #0768
On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4T
Junzhong Xu 1 , Mortiz Zaiss 2 , Zhongliang Zu 1 , Hua Li 1 , Jingping Xie 1 , Daniel F Gochberg 1 , Peter Bachert 2 , and John C Gore 1
1
Institute of Imaging Science, Vanderbilt
University, Nashville, Tennessee, United States,
2
German
Cancer Research Center, Heidelberg, Germany
A new three-offset 1/Z method was proposed to correct
spillover, MT and R1 (the longitudinal relaxation rate)
effects in chemical exchange saturation transfer (CEST)
imaging. The corrected APT in tumors was found not
significantly different from normal tissues, but
corrected NOE effects in tumors showed significant
decreases compared with normal tissues. These results
are consistent with biochemical measurements suggesting
that there is no significant enhancement of protein
contents in the tumors. Our results may assist better
understanding the contrast depicted by CEST imaging in
tumors, and the development of improved APT and NOE
measurements for cancer imaging.
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