Abstract #0773
Differentiating Injured and Normal Lungs by the Ratiometric Analysis of Hyperpolarized-13C-NMR Data
He N. Xu 1,2 , Hoora Shaghaghi 1 , Stephen Kadlececk 1 , Harrilla Profka 1 , Lin Z. Li 1,2 , and Rahim Rizi 1
1
Radiology Department, University of
Pennsylvania, Philadelphia, PA, United States,
2
Britton
Chance Lab of Redox Imaging, Johnson Research
Foundation, University of Pennsylvania, Philadelphia,
PA, United States
A non-invasive method for assessing lung injury is
needed. We aimed to identify an early metabolic
predictor of lung inflammation using the hyperpolarized
13C-NMR technique. Rat lung injury was induced by
bleomycin and studied by injecting hyperpolarized
13C-pyruvate to the perfused lung 7 and 21 days after
the treatment. The larger rate constants of the LDH-catalyzed
reaction quantified by the ratiometric analysis of the
time course of lactate/pyruvate ratio indicate
inflammation sped up both the forward and reverse
reaction rates and altered the cellular redox state. Our
results indicate that HP-13C-NMR data can be useful for
probing lung disorders.
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