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Abstract #0774

Regional Mapping of Gas Uptake by Lung Tissue and Blood in Subjects with Asthma using Hyperpolarized Xenon-129 MRI

Kun Qing 1 , Kai Ruppert 1,2 , Tally A. Altes 1 , Yun Jiang 3 , Jaime F. Mata 1 , G. Wilson Miller 1 , Yang Yang 1 , Yun M. Shim 1 , Steven Guan 1 , Iulian C. Ruset 4,5 , F. William Hersman 4,5 , and John P. Mugler 1

1 University of Virginia, Charlottesville, VA, United States, 2 Cincinnati Children's Hospital, Cincinnati, OH, United States, 3 Case Western Reserve University, Cleveland, OH, United States, 4 Xemed LLC, Durham, NH, United States, 5 University of New Hampshire, Durham, NH, United States

For this study, we used 3-D Xe-129 dissolved-phase imaging method to investigate functional changes in the lungs of 10 asthmatics, as compared to 12 healthy subjects. The relatively high RBC-to-tissue ratios, low tissue-to-gas ratios, and normal ADC values found in 7 asthmatics represent a unique combination that has not been seen in healthy or COPD subjects. These values may be associated with airway inflammation and remodeling of both the airways and vasculature. All ratios were low in two older asthmatics, indicating impaired gas exchange possibly due to emphysematous tissue destruction and thickening of alveolar walls, similar to COPD.

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