Abstract #0774
Regional Mapping of Gas Uptake by Lung Tissue and Blood in Subjects with Asthma using Hyperpolarized Xenon-129 MRI
Kun Qing 1 , Kai Ruppert 1,2 , Tally A. Altes 1 , Yun Jiang 3 , Jaime F. Mata 1 , G. Wilson Miller 1 , Yang Yang 1 , Yun M. Shim 1 , Steven Guan 1 , Iulian C. Ruset 4,5 , F. William Hersman 4,5 , and John P. Mugler 1
1
University of Virginia, Charlottesville, VA,
United States,
2
Cincinnati
Children's Hospital, Cincinnati, OH, United States,
3
Case
Western Reserve University, Cleveland, OH, United
States,
4
Xemed
LLC, Durham, NH, United States,
5
University
of New Hampshire, Durham, NH, United States
For this study, we used 3-D Xe-129 dissolved-phase
imaging method to investigate functional changes in the
lungs of 10 asthmatics, as compared to 12 healthy
subjects. The relatively high RBC-to-tissue ratios, low
tissue-to-gas ratios, and normal ADC values found in 7
asthmatics represent a unique combination that has not
been seen in healthy or COPD subjects. These values may
be associated with airway inflammation and remodeling of
both the airways and vasculature. All ratios were low in
two older asthmatics, indicating impaired gas exchange
possibly due to emphysematous tissue destruction and
thickening of alveolar walls, similar to COPD.
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