Abstract #0775
Dissolved Hyperpolarised 129Xe As A Probe Of Lung Function In Idiopathic Pulmonary Fibrosis And Systemic Sclerosis
Neil James Stewart 1 , General Leung 1 , Graham Norquay 1 , Helen Marshall 1 , Juan Parra-Robles 1 , Andy Swift 1 , Jan Wolber 1,2 , Rolf Schulte 3 , Nehal Hussain 4 , Robin Condliffe 4 , Charlie Elliot 4 , Philip Murphy 5 , Moira Whyte 4 , David Kiely 4 , and Jim Michael Wild 1
1
Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom,
2
GE
Healthcare, Amersham, Buckinghamshire, United Kingdom,
3
GE
Global Research, Garching, Bavaria, Germany,
4
Respiratory
Medicine, University of Sheffield, Sheffield, South
Yorkshire, United Kingdom,
5
GlaxoSmithKline,
Southall, Greater London, United Kingdom
In this work, hyperpolarised 129Xe was assessed as a
functional tool for the study of gas exchange in the
human lungs. The Chemical Shift Saturation Recovery
technique was utilised to quantify changes in lung
microstructure and consequent degradation of lung
function in subjects with idiopathic pulmonary fibrosis
and systemic sclerosis, via non-invasive measurement of
septal thickening and elevated pulmonary-capillary
transit times. The results of this study correlated well
with dynamic contrast enhanced MRI and hyperpolarised
3He diffusion MRI.
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