Diffusion Tensor Imaging of Human Brains In-vivo at 3 Tesla with Very High Spatial Resolution: 0.85mm x 0.85mm x 0.85 mm
Hing-Chiu Chang 1 , Shayan Guhaniyogi 1 , and Nan-Kuei Chen 1
Brain Imaging and Analysis Center, Duke
University Medical Center, Durham, North Carolina,
Progresses in MRI based connectivity network mapping for
translational neuroimaging is currently limited by the
spatial resolution that can be achieved with
conventional DTI protocols. The recent progress in 3D
multi-slab EPI sequence makes it possible to acquire
human DTI data with 1.3mm3 isotropic voxel size.
However, the in vivo human brain DTI at sub-millimeter
isotropic resolution, to our knowledge, has not yet been
routinely achieved yet. We integrated the 3D multi-slab
EPI acquisition and the multiplexed sensitivity encoding
(MUSE) post-processing algorithm, to acquire
high-quality and high-SNR human brain DTI data in vivo
at high spatial resolution: 0.85mm^3.
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