Diffusion Tensor Imaging of Human Brains In-vivo at 3 Tesla with Very High Spatial Resolution: 0.85mm x 0.85mm x 0.85 mm

Progresses in MRI based connectivity network mapping for translational neuroimaging is currently limited by the spatial resolution that can be achieved with conventional DTI protocols. The recent progress in 3D multi-slab EPI sequence makes it possible to acquire human DTI data with 1.3mm3 isotropic voxel size. However, the in vivo human brain DTI at sub-millimeter isotropic resolution, to our knowledge, has not yet been routinely achieved yet. We integrated the 3D multi-slab EPI acquisition and the multiplexed sensitivity encoding (MUSE) post-processing algorithm, to acquire high-quality and high-SNR human brain DTI data in vivo at high spatial resolution: 0.85mm^3.

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