Abstract #0808
Chronic Hepatic Encephalopathy in the developing and adult rat brain: an in vivo non-invasive and longitudinal metabolic investigation using 1H MRS, DTI and immunohistochemistry
Veronika Rackayov 1 , Olivier Braissant 2 , Valrie A. McLin 3 , and Cristina Cudalbu 4
1
Laboratory for Functional and Metabolic
Imaging, Center for Biomedical Imaging, Ecole
Polytechnique Fdrale de Lausanne (EPFL), Lausanne,
Vaud, Switzerland,
2
Laboratoire
de Chimie Clinique, Centre Hospitalier Universitaire
Vaudois and University of Lausanne, Lausanne, Vaud,
Switzerland,
3
Swiss
Center for Liver Disease in Children, Department of
Pediatrics, University Hospitals Geneva, Geneva,
Switzerland,
4
Centre
dImagerie Biomedicale (CIBM), Ecole Polytechnique
Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland
Chronic liver disease affects both adults and children
and is often associated with some degree of hepatic
encephalopathy (HE). In childhood, acute hyperammonemia
(HA) is associated with brain edema and leads to
irreversible damage of the developing central nervous
system (CNS). Although cognitive deficits exist in
children with CLD, the underlying mechanism is unclear
[2]. How the developing brain responds to the metabolic
changes of CLD, and how these mechanisms differ from
those in adult patients are two unknowns. We
hypothesized that blood-brain-barrier permeability and
energy metabolism may be different in adult and
developing brain.
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