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Abstract #0809

1H functional MRS of the rat barrel cortex and the thalamus during trigeminal nerve stimulation. Preliminary investigation of the metabolic regulation of the barrel cortex by glutamatergic and GABAergic thalamocortical inputs.

Nathalie Just 1 , Carola Jaquelina Romero 2 , and Rolf Gruetter 1,3

1 CIBM-AIT, EPFL, Lausanne, Switzerland, 2 Laboratory for functional and metabolic Imaging, EPFL, Lausanne, Switzerland, 3 Departments of Radiology, University of Lausanne and University of Geneva, Lausanne and Geneva, Switzerland

To date the metabolic mechanisms of regulation of the barrel cortex by thalamocortical transmissions remain unclear. In the present work, the neurochemical profiles of the barrel cortex and thalamus were measured using functional MRS during 32-minute periods of rest and trigeminal nerve stimulation. Significant changes in Lactate and Glutamate were estimated in both structures during stimulation. In addition, GABA and Glutamate levels were correlated within or between each structure. GABA levels in the thalamus were linearly correlated to GABA levels in S1BF during activation. Upon validation, these results should contribute to the accurate interpretation of functional neuroimaging signals.

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