1H functional MRS of the rat barrel cortex and the thalamus during trigeminal nerve stimulation. Preliminary investigation of the metabolic regulation of the barrel cortex by glutamatergic and GABAergic thalamocortical inputs.
Nathalie Just 1 , Carola Jaquelina Romero 2 , and Rolf Gruetter 1,3
CIBM-AIT, EPFL, Lausanne, Switzerland,
for functional and metabolic Imaging, EPFL, Lausanne,
of Radiology, University of Lausanne and University of
Geneva, Lausanne and Geneva, Switzerland
To date the metabolic mechanisms of regulation of the
barrel cortex by thalamocortical transmissions remain
unclear. In the present work, the neurochemical profiles
of the barrel cortex and thalamus were measured using
functional MRS during 32-minute periods of rest and
trigeminal nerve stimulation. Significant changes in
Lactate and Glutamate were estimated in both structures
during stimulation. In addition, GABA and Glutamate
levels were correlated within or between each structure.
GABA levels in the thalamus were linearly correlated to
GABA levels in S1BF during activation. Upon validation,
these results should contribute to the accurate
interpretation of functional neuroimaging signals.
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