Abstract #0809
1H functional MRS of the rat barrel cortex and the thalamus during trigeminal nerve stimulation. Preliminary investigation of the metabolic regulation of the barrel cortex by glutamatergic and GABAergic thalamocortical inputs.
Nathalie Just 1 , Carola Jaquelina Romero 2 , and Rolf Gruetter 1,3
1
CIBM-AIT, EPFL, Lausanne, Switzerland,
2
Laboratory
for functional and metabolic Imaging, EPFL, Lausanne,
Switzerland,
3
Departments
of Radiology, University of Lausanne and University of
Geneva, Lausanne and Geneva, Switzerland
To date the metabolic mechanisms of regulation of the
barrel cortex by thalamocortical transmissions remain
unclear. In the present work, the neurochemical profiles
of the barrel cortex and thalamus were measured using
functional MRS during 32-minute periods of rest and
trigeminal nerve stimulation. Significant changes in
Lactate and Glutamate were estimated in both structures
during stimulation. In addition, GABA and Glutamate
levels were correlated within or between each structure.
GABA levels in the thalamus were linearly correlated to
GABA levels in S1BF during activation. Upon validation,
these results should contribute to the accurate
interpretation of functional neuroimaging signals.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
