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Abstract #0815

Morphological and quantitative ultrashort echo time (UTE) magnetic resonance imaging of the short T2 components in white matter of the brain

Jiang Du 1 , Vipul Sheth 1 , Shihong Li 1 , Michael Carl 2 , Scott Vandenberg 3 , Jody Corey-Bloom 4 , and Graeme Bydder 1

1 Radiology, University of California, San Diego, San Diego, CA, United States, 2 General Electric, Global MR Applications & Workflow, San Diego, CA, United States, 3 Pathology, University of California, San Diego, La Jolla, CA, United States, 4 Neurosciences, University of California, San Diego, La Jolla, CA, United States

Myelin is a lamellar membranous structure consisting of alternating protein and lipid layers. Researchers have been working for decades to develop MRI techniques to assess myelin in vivo. The non-water protons in myelin and tightly bound water have very short T2s and are invisible with conventional clinical sequences. We have implemented a 2D adiabatic inversion recovery prepared dual echo ultrashort echo time (2D IR-dUTE) acquisition with a TE of 8 us. In this study we aimed to morphologically and quantitatively evaluate myelin and tightly bound water in white matter of the brain of normal volunteers at 3T.

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