Abstract #0835
Quantitative T1rho Mapping of Bipolar Disorder: Basal Differences in Euthymia
Casey P. Johnson 1 , Robin L. Follmer 2 , Ipek Oguz 3 , Lois A. Warren 2 , Gary E. Christensen 3 , Jess G. Fiedorowicz 2 , Vincent A. Magnotta 1,2 , and John A. Wemmie 2,4
1
Radiology, University of Iowa, Iowa City,
IA, United States,
2
Psychiatry,
University of Iowa, Iowa City, IA, United States,
3
Electrical
and Computer Engineering, University of Iowa, Iowa City,
IA, United States,
4
Veteran
Affairs Hospital Center, Iowa City, IA, United States
We investigated the hypothesis that metabolism is
abnormal in patients with bipolar disorder vs. normal
controls using 3D quantitative T1ρ mapping. The T1ρ
relaxation time has been shown to be sensitive to
byproducts of metabolism including pH and metabolite
concentrations. We observed that T1ρ is elevated in a
euthymic case group, with evidence for a whole-brain
difference as well as focal changes that exceed the
global effect. This study furthers our understanding of
bipolar disorder, identifies regions of interest to
probe in future studies, and establishes T1ρ as a
potential marker for abnormal metabolism in psychiatric
diseases.
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