Abstract #0834
Brain iron accumulation in first episode of mania
Vanessa Wiggermann 1,2 , Enedino Hernndez Torres 1,3 , Leonardo E. da Silveira 4 , Lakshmi N. Yatham 4 , and Alexander Rauscher 1,3
1
Radiology, University of British Columbia,
Vancouver, BC, Canada,
2
Physics
and Astronomy, University of British Columbia,
Vancouver, BC, Canada,
3
UBC MRI Research
Centre, Vancouver, BC, Canada,
4
Psychiatry,
University of British Columbia, Vancouver, BC, Canada
Many psychiatric disorders are suggested to relate to
metabolite changes and oxidative stress, which may be
associated with iron accumulation in the brain. Here, we
used susceptibility-sensitive gradient echo imaging to
compare MR resonance frequency shifts and R2* relaxation
rates in the deep brain gray matter between first
episode mania patients and healthy controls. We found
significant increases in MR resonance frequency in the
caudate and the globus pallidus and a significant
reduction in the ventral striatum in patients compared
to controls. However, we observed no differences in R2*
values between patients and healthy controls.
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