Abstract #0833
Evaluation of brain complexity in psychiatric patients using fractal geometry
Letizia Squarcina 1 , Alberto De Luca 2 , Marcella Bellani 1 , Paolo Brambilla 3,4 , Federico E Turkheimer 5 , and Alessandra Bertoldo 2
1
Section of Psychiatry, AOUI Verona, Verona,
VR, Italy,
2
Department
of Information Engineering, University of Padova, Padova,
PD, Italy,
3
University
of Udine, Udine, UD, Italy,
4
Dept.
of Psychiatry and Behavioral Sciences, University of
Texas Medical School, Houston, TX, United States,
5
King's
College London, London, United Kingdom
With this study, we used fractal geometry to analyze T1
data of patients affected by schizophrenia or bipolar
disorder. We applied the box-count algorithm on
segmented data and a modified, local version of it on
non-segmented data, to compute fractal dimension both on
the whole brain and in substructures. We found a marked
difference on fractal dimension values in patients in
respect to healthy controls. Fractal dimension is
reduced in patients, with a visible effect especially in
frontal lobe, which confirms previous findings of
modification of this structures in these diseases.
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