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Abstract #0832

Subtypes of nucleus accumbens activations for anticipation of gains and losses in healthy and depressed subjects

Masaya Misaki 1 , Teresa Victor 1 , Hideo Suzuki 1 , Kent Teague 2 , Brent McKinney 3 , Patrick Bellgowan 1,4 , Jonathan Savitz 1,4 , Wayne Drevets 1,5 , and Jerzy Bodurka 1,6

1 Laureate Institute for Brain Research, Tulsa, OK, United States, 2 Dept. of Surgery, University of Oklahoma College of Medicine, OK, United States, 3 Dept. of Mathematical and Computer Sciences, University of Tulsa, OK, United States, 4 Dept. of Medicine, Tulsa School of Community Medicine, University of Tulsa, OK, United States, 5 Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ, United States, 6 College of Engineering, University of Oklahoma, OK, United States

Subtypes of nucleus accumbens (NAcc) activation for anticipation of gains and losses were identified for healthy and major depressive disorder (MDD) subjects. We used hierarchical clustering analysis to categorize NAcc activation patterns in individual subjects. Majority of subjects had typical NAcc activity; increased activity to gain and less active to loss. Hyper- and hypo-active subtypes were also found, which showed increase or decreased activity to both gains and losses. These hyper- and hypo-active types were seen in both healthy and MDD groups with the same percentage. In MDD subjects, however, subjects with the hypo-active NAcc had more severe depression symptoms.

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