Abstract #0831
Dietary Nitrate Does Not Induce Hypoxia Dependent Augmented Oxygen Delivery in Skeletal Muscle in Young Healthy Subjects.
Rachel Bentley 1 , Stuart R Gray 2 , Christian Schwarzbauer 1 , Dana Dawson 3 , Michael P Frenneaux 3 , and Jiabao He 1
1
Aberdeen Biomedical Imaging Centre,
University of Aberdeen, Aberdeen, Aberdeenshire,
United Kingdom,
2
Musculoskeletal
Research Programme, University of Aberdeen,
Aberdeen, Aberdeenshire, United Kingdom,
3
Cardiovascular
Research Programme, University of Aberdeen,
Aberdeen, Aberdeenshire, United Kingdom
Dietary nitrate improves skeletal muscle
metabolic efficiency, and might induce hypoxia
dependent vasodilation and consequently augment
oxygen delivery. We conducted dual echo gradient
echo muscle fMRI study to evaluate tissue
oxygenation during plantar flexion exercise at
15% and 25% maximum voluntary contraction (MVC).
Significant decreases in maximal percentage
change were found in soleus (p=0.004) and
gastrocnemius (p=0.017) at 15% MVC, but not at
25% MVC. This reduction is primarily found in
type 1 muscle groups at lower exercise
intensity, indicating that dietary nitrate
affects skeletal muscle via enhancements in
mitochondrial function instead of vascular
effects in young healthy subjects.
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