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Abstract #0831

Dietary Nitrate Does Not Induce Hypoxia Dependent Augmented Oxygen Delivery in Skeletal Muscle in Young Healthy Subjects.

Rachel Bentley 1 , Stuart R Gray 2 , Christian Schwarzbauer 1 , Dana Dawson 3 , Michael P Frenneaux 3 , and Jiabao He 1

1 Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Aberdeenshire, United Kingdom, 2 Musculoskeletal Research Programme, University of Aberdeen, Aberdeen, Aberdeenshire, United Kingdom, 3 Cardiovascular Research Programme, University of Aberdeen, Aberdeen, Aberdeenshire, United Kingdom

Dietary nitrate improves skeletal muscle metabolic efficiency, and might induce hypoxia dependent vasodilation and consequently augment oxygen delivery. We conducted dual echo gradient echo muscle fMRI study to evaluate tissue oxygenation during plantar flexion exercise at 15% and 25% maximum voluntary contraction (MVC). Significant decreases in maximal percentage change were found in soleus (p=0.004) and gastrocnemius (p=0.017) at 15% MVC, but not at 25% MVC. This reduction is primarily found in type 1 muscle groups at lower exercise intensity, indicating that dietary nitrate affects skeletal muscle via enhancements in mitochondrial function instead of vascular effects in young healthy subjects.

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