Abstract #0830
Feasibility and Reproducibility of Measurement of Skeletal Muscle Blood Flow, Oxygen Extraction and VO2 with Dynamic Exercise Using MRI
Kory W. Mathewson 1 , Mark Haykowsky 2 , and Richard B. Thompson 1
1
Biomedical Engineering, University
of Alberta, Edmonton, Alberta, Canada,
2
Faculty
of Rehabilitation, University of Alberta,
Edmonton, Alberta, Canada
We propose a new imaging approach which
interleaves complex-difference and susceptometry
MRI acquisitions for real-time imaging of
skeletal muscle blood flow (SMBF) and venous
oxygen saturation (SvO2) for the calculation of
skeletal muscle oxygen consumption (VO2). The
goal of this study was to determine the
reproducibility of this approach during
sub-maximal knee-extensor exercise. The
coefficient of variation from test/retest trials
was 7.6%, 15.6% and 12.3% for SMBF, SvO2 and
VO2, with mean values of 0.90.1L/min/kg,
43.213.5% and 95.718.0mL/min/kg respectively.
To our knowledge, this is the first report of
non-invasive skeletal muscle VO2 and its
determinants (SMFB,SvO2) during dynamic
exercise.
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