Mapping the Unidirectional Pi-to-ATP Fluxes in Muscles of the Lower Leg by Using Progressive Saturation 31P-MRI with PCr Suppression at 7.0 T

Phosphorus saturation transfer methods can assess the turnover rates of important metabolic reactions such as the adenosine triphosphate (ATP) synthesis/hydrolysis cycle. In this study, we focused on the development and implementation of an imaging method for simultaneously measuring the kinetics of ATP synthesis and the Pi-to-ATP fluxes in muscles of the lower leg. Mapping the kinetics of the ATP synthesis reaction and the Pi-to-ATP fluxes in several muscles of the leg using our imaging method could provide useful insights into the study of diseases such as insulin resistance and diabetes.

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